How do NLRP3 inflammasome and mitophagy pathways mechanistically interact in microglia?

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Description

The highest-ranked hypothesis proposed NLRP3/mitophagy coupling modulation, but the specific molecular crosstalk mechanisms between these pathways in microglial cells remain undefined. Understanding this interaction is essential for targeted intervention.

Source: Debate session sess_SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402 (Analysis: SDA-2026-04-03-gap-immune-atlas-neuroinflam-20260402)

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