How do species differences in P2RX7 function between rodents and humans affect therapeutic translation?

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Description

The debate noted significant functional differences in P2RX7 between rodent models and human microglia. These differences could explain preclinical-clinical translation failures but remain mechanistically uncharacterized.

Source: Debate session sess_SDA-2026-04-03-gap-tau-prop-20260402003221 (Analysis: SDA-2026-04-03-gap-tau-prop-20260402003221)

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