How does TFEB-PGC1α decoupling create selective neuronal vulnerability to protein aggregation?

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Description

The hypothesis of mitochondrial-lysosomal coupling failure was proposed but the specific molecular mechanisms linking TFEB downregulation to amyloid/tau sensitivity remain unclear. This gap limits understanding of how aging creates neurodegeneration susceptibility.

Source: Debate session sess_SDA-2026-04-02-gap-aging-mouse-brain-v5-20260402 (Analysis: SDA-2026-04-02-gap-aging-mouse-brain-v5-20260402)

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