Which specific cell types drive complement system activation in the aging brain?

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Description

The debate established complement activation as a key aging signature but did not resolve whether microglia, astrocytes, or neurons are the primary cellular sources. Cell-type specificity is crucial for targeted therapeutic approaches and understanding disease mechanisms.

Source: Debate session sess_SDA-2026-04-02-gap-aging-mouse-brain-v5-20260402 (Analysis: SDA-2026-04-02-gap-aging-mouse-brain-v5-20260402)

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