Can selective modulation of 14-3-3 protein isoforms differentially affect tau propagation versus normal tau function?

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Description

The debate mentioned GSK3β-YWHAZ interactions and 14-3-3 protein-mediated tau stabilization but didn’t address whether different 14-3-3 isoforms have distinct roles in propagation. This isoform-specific targeting could provide therapeutic selectivity while avoiding disruption of essential tau functions.

Source: Debate session sess_SDA-2026-04-02-gap-tau-prop-20260402003221 (Analysis: SDA-2026-04-02-gap-tau-prop-20260402003221)

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