What are the optimal temporal dynamics for GSK3β inhibition to block pathological tau phosphorylation while preserving physiological cycles?

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Composite

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Novelty

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Mechanistic

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Druggability

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Priority

78%

Importance

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Tractability

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Market price

50%

Description

The debate identified GSK3β as highly druggable with existing clinical compounds, but failed to resolve the critical timing parameters needed to selectively target pathological versus normal tau phosphorylation. This mechanistic gap directly impacts therapeutic window and dosing strategies.

Source: Debate session sess_SDA-2026-04-02-gap-tau-prop-20260402003221 (Analysis: SDA-2026-04-02-gap-tau-prop-20260402003221)

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