Which specific HSP90 co-chaperone interactions promote versus prevent tau pathogenesis and propagation?

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Description

The debate revealed contradictory evidence about HSP90’s role, with some data suggesting it promotes tau pathogenesis while the hypothesis proposed stabilizing native conformations. The specific co-chaperone networks that determine HSP90’s net effect on tau propagation remain unresolved.

Source: Debate session sess_SDA-2026-04-02-gap-tau-prop-20260402003221 (Analysis: SDA-2026-04-02-gap-tau-prop-20260402003221)

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