What are validated biomarkers for measuring senescent cell clearance and target engagement in the living brain?

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Description

The Expert noted that senolytics lack validated biomarkers for in vivo target engagement, making clinical development nearly impossible. This represents a critical translational bottleneck for all senescence-based neurotherapies discussed.

Source: Debate session sess_SDA-2026-04-02-gap-senescent-clearance-neuro (Analysis: SDA-2026-04-02-gap-senescent-clearance-neuro)

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