Do senescent neurons become 'super-spreaders' of pathological tau through enhanced exosome production?

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Description

The highest-ranked hypothesis proposed that senescent cells amplify tau propagation via exosomes, but this mechanistic link was not established in the literature cited. This represents a key gap connecting cellular senescence to protein aggregation diseases.

Source: Debate session sess_SDA-2026-04-02-gap-senescent-clearance-neuro (Analysis: SDA-2026-04-02-gap-senescent-clearance-neuro)

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