Which downstream TREM2 signaling pathways should be selectively modulated for therapeutic benefit?

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Composite

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Novelty

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Mechanistic

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Druggability

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Priority

75%

Importance

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Tractability

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Market price

50%

Description

While TREM2’s importance is established, the debate reveals uncertainty about which specific downstream effectors to target. This mechanistic gap limits development of precision therapeutics beyond crude agonism/antagonism approaches.

Source: Debate session sess_SDA-2026-04-02-gap-001 (Analysis: SDA-2026-04-02-gap-001)

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