How do circadian clock gene variants modify individual susceptibility to sleep-related neurodegeneration?

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Description

The debate acknowledged circadian disruption’s role but did not address genetic heterogeneity in clock function. Understanding how CLOCK, BMAL1, and PER variants influence disease risk could enable personalized sleep interventions and identify high-risk populations.

Source: Debate session sess_SDA-2026-04-02-gap-20260402-003058 (Analysis: SDA-2026-04-02-gap-20260402-003058)

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