How can TREM2 modulation be restricted to microglia without affecting oligodendrocytes and astrocytes?

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Description

The skeptic noted TREM2 expression in multiple CNS cell types as a critical confound, but no cell-selective targeting approaches were discussed. This gap could lead to unexpected therapeutic effects.

Source: Debate session sess_SDA-2026-04-01-gap-001 (Analysis: SDA-2026-04-01-gap-001)

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