What determines the efficiency and specificity of base editing in post-mitotic neurons for therapeutic applications?

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Description

The debate identified extremely low base editing efficiency (1-5%) in neurons as a major barrier to APOE4-to-APOE3 conversion therapy. The molecular factors governing editing success in non-dividing brain cells remain poorly understood, limiting the development of CNS gene editing approaches.

Source: Debate session sess_SDA-2026-04-01-gap-010 (Analysis: SDA-2026-04-01-gap-010)

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