What are the endogenous signals that trigger astrocytes to initiate mitochondrial donation to metabolically stressed neurons?

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Description

The debate proposed AMPK hypersensitivity as a therapeutic approach but didn’t identify the natural communication pathways between distressed neurons and donor astrocytes. Understanding these signals is key for developing physiologically relevant interventions.

Source: Debate session sess_SDA-2026-04-01-gap-v2-89432b95 (Analysis: SDA-2026-04-01-gap-v2-89432b95)

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