What is the therapeutic window for HDAC3 inhibition that preserves circadian function while resetting epigenetic clocks?

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Description

The debate identified a critical conflict: HDAC3 inhibition may reset aging clocks but also disrupts essential circadian rhythms. The Synthesizer noted safety concerns but no resolution was provided for balancing therapeutic benefits against circadian disruption.

Source: Debate session sess_SDA-2026-04-01-gap-v2-bc5f270e (Analysis: SDA-2026-04-01-gap-v2-bc5f270e)

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