How can TET2 overexpression achieve site-specific demethylation without global genomic disruption?

molecular biology resolved
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Description

The Theorist proposed TET2 therapy for targeted demethylation, but the Skeptic highlighted the lack of specificity and potential for developmental disruption. No mechanism was provided for achieving selective demethylation at pathological sites while preserving essential methylation patterns.

Source: Debate session sess_SDA-2026-04-01-gap-v2-bc5f270e (Analysis: SDA-2026-04-01-gap-v2-bc5f270e)

Evidence summary

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