Which cryptic exon inclusion events are functionally relevant versus bystander effects in RBP-mediated neurodegeneration?

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The cryptic exon silencing hypothesis achieved high scores but lacked specificity about which aberrant splicing events actually contribute to pathology versus those that are merely correlated. Identifying causal events is crucial for antisense oligonucleotide design.

Source: Debate session sess_SDA-2026-04-01-gap-v2-68d9c9c1 (Analysis: SDA-2026-04-01-gap-v2-68d9c9c1)

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