What are the structural determinants that enable cross-seeding between different amyloidogenic proteins?

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Description

The debate assumed shared β-sheet conformations enable cross-seeding but didn’t identify specific structural motifs or binding interfaces. Understanding these determinants is critical for designing targeted interventions and predicting cross-seeding propensity.

Source: Debate session sess_SDA-2026-04-01-gap-9137255b (Analysis: SDA-2026-04-01-gap-9137255b)

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