How can PDGFR-β signaling be selectively biased toward contractility pathways while avoiding proliferative responses?

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Description

The theorist proposed biased PDGFR-β agonism targeting PI3K/Akt while avoiding MAPK activation, but the specific molecular mechanisms for achieving this selectivity remain undefined. This represents a critical druggability challenge for pericyte-targeted therapies.

Source: Debate session sess_SDA-2026-04-01-gap-v2-ee5a5023 (Analysis: SDA-2026-04-01-gap-v2-ee5a5023)

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