Do PSP and CBD tau strains have distinct heparan sulfate binding specificities that determine astrocytic morphology?

The debate cited general tau-HSPG interactions but lacked strain-specific evidence. The Skeptic noted this critical gap prevents validating glycocalyx remodeling as a therapeutic approach. Direct binding studies comparing PSP vs CBD tau strains to different HSPG compositions are needed.

Source: Debate session sess_SDA-2026-04-01-gap-005 (Analysis: SDA-2026-04-01-gap-005)

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