What is the temporal sequence of gut barrier dysfunction relative to CNS α-synuclein pathology in PD progression?

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Description

The debate discussed gut-brain axis communication but did not resolve whether intestinal permeability changes precede or follow neurodegeneration. Understanding this timeline is crucial for determining therapeutic windows and intervention strategies.

Source: Debate session sess_SDA-2026-04-01-gap-20260401-225155 (Analysis: SDA-2026-04-01-gap-20260401-225155)

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