How do P2Y1/P2X7 receptor ratios mechanistically control astrocyte phenotype switching at the molecular level?

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Description

While the purinergic hypothesis scored highest for feasibility, the specific intracellular signaling cascades linking receptor ratios to transcriptional programs remain undefined. Understanding these pathways is essential for rational drug combination design.

Source: Debate session sess_SDA-2026-04-01-gap-007 (Analysis: SDA-2026-04-01-gap-007)

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