Do GPR32 superagonists cause receptor desensitization that limits therapeutic efficacy?

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Description

The skeptic raised concerns about supraphysiological GPR32 activation leading to desensitization, but no data addressed this critical dose-response relationship. Understanding receptor kinetics is essential for therapeutic development.

Source: Debate session sess_SDA-2026-04-01-gap-014 (Analysis: SDA-2026-04-01-gap-014)

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