What is the cell-type-specific expression pattern of LDHB in PV interneurons versus other neuronal populations in AD?

metabolic neuroscience open composite 66%
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Description

The LDHB hypothesis assumes PV interneurons preferentially express this isoform, but the debate noted this metabolic specialization hasn’t been validated in human AD tissue. Single-cell metabolic profiling could reveal whether LDHB targeting would be PV-selective.

Source: Debate session sess_SDA-2026-04-16-gap-20260416-133111 (Analysis: SDA-2026-04-16-gap-20260416-133111)

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