Which complement pathway components show the strongest correlation with PV interneuron loss in human AD progression?

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Composite

68%

Novelty

70%

Mechanistic

—

Druggability

—

Priority

69%

Importance

82%

Tractability

75%

Market price

50%

Description

While C3 pathway activation was identified as druggable, the debate didn’t establish which specific complement proteins drive PV interneuron vulnerability versus general neuroinflammation. This mechanistic specificity is needed to select optimal therapeutic targets within the complement cascade.

Source: Debate session sess_SDA-2026-04-16-gap-20260416-133111 (Analysis: SDA-2026-04-16-gap-20260416-133111)

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