What is the structural basis for small molecule recognition by complement protein C1q?

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Composite

69%

Novelty

90%

Mechanistic

—

Druggability

—

Priority

75%

Importance

75%

Tractability

80%

Market price

50%

Description

C1q lacks known druggable pockets yet allegedly binds Alectinib with high affinity. Resolving whether C1q can accommodate small molecules would establish druggability principles for this ‘undruggable’ target class and inform complement modulator design.

Source: Debate session sess_SDA-2026-04-16-gap-pubmed-20260410-095709-4e97c09e (Analysis: SDA-2026-04-16-gap-pubmed-20260410-095709-4e97c09e)

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