How do gC1qR surface expression levels affect microglial C1q signaling in neurodegeneration?

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Description

The debate highlighted gC1qR as a potential indirect target but its activation-dependent surface translocation from mitochondria remains poorly characterized. Understanding this regulation could identify new intervention points for complement-mediated synaptic pruning.

Source: Debate session sess_SDA-2026-04-16-gap-pubmed-20260410-095709-4e97c09e (Analysis: SDA-2026-04-16-gap-pubmed-20260410-095709-4e97c09e)

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