Can C1q-mediated synaptic pruning be blocked without impairing Aβ clearance functions?

immunology open composite 72%
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Description

Multiple hypotheses assume these functions are separable, but the debate revealed conflicting evidence about whether the same C1q protein mediates both processes through overlapping mechanisms. Resolving this is critical for therapeutic selectivity.

Source: Debate session sess_SDA-2026-04-12-gap-debate-20260410-112848-7ba6c2e1 (Analysis: SDA-2026-04-12-gap-debate-20260410-112848-7ba6c2e1)

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