What are the druggable differences between C1q binding interfaces for neuronal membranes versus Aβ?

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Composite

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Description

Hypothesis 2 proposed targeting distinct C1q binding domains, but the debate did not establish whether these interfaces are structurally distinct enough for selective inhibition. This structural biology gap limits rational drug design approaches.

Source: Debate session sess_SDA-2026-04-12-gap-debate-20260410-112848-7ba6c2e1 (Analysis: SDA-2026-04-12-gap-debate-20260410-112848-7ba6c2e1)

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