Gut-Brain Axis in Parkinson's Disease: Molecular Mechanisms, Neuroinflammation, and Therapeutic Strategies

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Description

What are the key molecular mechanisms by which gut microbiome dysbiosis drives neuroinflammation, alpha-synuclein aggregation, and dopaminergic neurodegeneration in Parkinson’s disease via the gut-brain axis, and which microbiome-targeting therapeutic strategies (FMT, probiotics, prebiotics, vagus nerve modulation) show the most promise for disease modification?

Resolution criteria

Resolved when a debate-backed evidence bundle identifies microbiome taxa or metabolites that causally alter alpha-synuclein aggregation, neuroinflammation, and dopaminergic neuron loss in Parkinson models, demonstrates rescue or worsening after microbiome modulation in at least two independent systems including one mammalian model, reports effect sizes for pathology and motor outcomes, and records the taxa-metabolite-pathway-disease KG edges plus a dataset of interventions and outcomes.

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