[landscape-gap] Cell Type Connectivity & Electrophysiology: Human Patch-seq data is extremely scarce; most connectivity-transcriptomics linking is from mouse; in vivo functional characterization of human cell types is nearly absent.

human-brain-cell-types open composite 84%
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Composite
84%
Novelty
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Priority
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Importance
87%
Tractability
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Market price
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Description

Linking cell type identity (transcriptomic) to electrophysiological properties, morphology, and connectivity patterns. Includes Patch-seq, EM-connectomics, and functional characterization of cell-type-specific circuits. | Gap: Human Patch-seq data is extremely scarce; most connectivity-transcriptomics linking is from mouse; in vivo functional characterization of human cell types is nearly absent.

Resolution criteria

Resolution requires: (1) >=50 human Patch-seq recordings from >=3 brain regions with matched transcriptomics + electrophysiology + morphology; (2) Cross-species connectivity mapping with AUC >= 0.75 for cell type matching; (3) Functional validation of >=5 human-specific connectivity predictions via optogenetics/chemogenetics; (4) KG edges linking cell types to connectivity patterns. Deliverable: human Patch-seq dataset + cross-species pipeline.

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