[landscape-gap] Epigenomic Cell Type Specification: Cell-type-specific cis-regulatory element atlases are incomplete for human brain; variant-to-cell-type mapping for non-coding GWAS loci is sparse.

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Description

Cell type-specific chromatin accessibility (scATAC-seq), DNA methylation, histone modifications, and 3D genome organization in human brain cell types. Includes regulatory element annotation and cell-type-specific enhancer-gene linking. | Gap: Cell-type-specific cis-regulatory element atlases are incomplete for human brain; variant-to-cell-type mapping for non-coding GWAS loci is sparse.

Resolution criteria

Resolution requires: (1) scATAC-seq atlas of >=5 human brain regions with >=100K cells and >=3 donors per region; (2) Cell-type-specific enhancer-gene linking for >=80% of GWAS neurodegeneration loci; (3) Cross-platform validation showing >=0.75 correlation; (4) KG edges connecting regulatory elements to target genes. Deliverable: epigenomic atlas + regulatory network.

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