[landscape-frontier] GWAS & Genetic Cell Type Enrichment: Cell-type enrichment results vary across methods; fine-mapping to causal cell types is inconclusive; rare variant cell-type effects are largely unexplored.

human-brain-cell-types open composite 55%
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Description

Mapping genetic disease risk (GWAS loci) to specific brain cell types using single-cell expression data. Includes MAGMA-cell, LDSC-SEG, and single-cell Mendelian randomization approaches for neuropsychiatric and neurodegenerative diseases. | Frontier: Cell-type enrichment results vary across methods; fine-mapping to causal cell types is inconclusive; rare variant cell-type effects are largely unexplored.

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