[landscape-gap] Organoid & In Vitro Cell Type Models: Organoid cell types diverge from in vivo counterparts in maturity and diversity; standardized organoid-to-primary comparison frameworks are missing.

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Description

Brain organoid and iPSC-derived cell type characterization and comparison to primary human brain cell types. Includes organoid atlases, fidelity assessment, and maturation state analysis. | Gap: Organoid cell types diverge from in vivo counterparts in maturity and diversity; standardized organoid-to-primary comparison frameworks are missing.

Resolution criteria

Resolution requires: (1) Published organoid-to-primary human brain cell type comparison framework with quantitative fidelity metrics (snRNA-seq correlation >= 0.75, AUC >= 0.80); (2) Single-cell atlas of >=3 organoid systems compared to primary human brain reference; (3) Standardized maturity markers demonstrating >=1 year maturation equivalence; (4) KG nodes linking organoid cell types to in vivo counterparts. Deliverable: peer-reviewed dataset + analysis notebook.

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