[landscape-gap] Brain Region-Specific Cell Atlases: Many subcortical regions (thalamus, hypothalamus, amygdala) lack comprehensive single-cell atlases in human; most data is from cortex and hippocampus.

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Composite

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Market price

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Description

Detailed cell-type atlases for individual human brain regions: hippocampus, striatum, cerebellum, substantia nigra, thalamus, amygdala, hypothalamus. Includes region-specific cell types not found in neocortex. | Gap: Many subcortical regions (thalamus, hypothalamus, amygdala) lack comprehensive single-cell atlases in human; most data is from cortex and hippocampus.

Resolution criteria

Resolution requires: (1) Single-cell atlas of >=3 subcortical regions with >=10K cells per region; (2) Cross-region classification pipeline achieving >=90% accuracy; (3) Identification of >=5 region-specific marker genes validated by in situ hybridization; (4) KG nodes for subcortical cell types. Deliverable: subcortical atlas + classification pipeline.

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