Gap in Synthetic Biology Lineage Tracing: Crispr Delivery Systems For In Vivo Therapeutic Applications

synthetic-biology-lineage-tracing proposed composite 80%
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Composite
80%
Novelty
65%
Mechanistic
—
Druggability
—
Priority
80%
Importance
80%
Tractability
76%
Market price
50%

Description

Priority frontier extracted from landscape commentary: CRISPR delivery systems for in vivo therapeutic applications.

Resolution criteria

Resolution requires: (1) CRISPR delivery system achieving >=40% editing efficiency in >=2 target tissues in vivo; (2) Off-target analysis showing <=1% indel frequency at top-10 off-target sites; (3) Delivery validated for cargo up to 10kb; (4) Standardized characterization protocol adopted by >=1 consortium. Deliverable: delivery system + characterization protocol.

Evidence summary

CRISPR delivery systems for in vivo therapeutic applications

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