How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit liquid-liquid phase separation?

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Description

The study shows that G3BP1 ubiquitination inhibits LLPS in vitro, but the molecular mechanism by which K63-linked ubiquitin chains prevent phase separation is not explained. Understanding this mechanism is crucial for developing targeted therapies for neurodegenerative diseases where pathological stress granules persist.

Gap type: unexplained_observation Source paper: Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules. (2023, Autophagy, PMID:36692217)

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