What determines the spatial organization of autophagy receptors at stress granule periphery versus core?

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Description

SQSTM1 and CALCOCO2 specifically localize to SG periphery rather than throughout the granule, but the mechanisms controlling this spatial restriction are unknown. This organization likely determines efficiency of SG clearance and could be dysregulated in neurodegeneration.

Gap type: unexplained_observation Source paper: Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules. (2023, Autophagy, PMID:36692217)

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