Why does prolonged anesthesia cause both cognitive dysfunction and anxiety through the same synaptic mechanism?

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Description

The study reports that complement-mediated synaptic elimination produces both cognitive deficits and anxiety-like behaviors, but doesn’t explain how the same hippocampal synaptic loss generates these distinct behavioral phenotypes. This mechanistic gap limits understanding of perioperative neurocognitive disorders.

Gap type: unexplained_observation Source paper: Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors. (2023, BMC Med, PMID:36600274)

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