How does sevoflurane-induced NF-κB activation specifically trigger complement cascade initiation?

neuroinflammation partially_addressed
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Description

While the study demonstrates both NF-κB pathway activation and increased C1qa expression after prolonged anesthesia, the mechanistic link between neuroinflammation and complement activation remains unclear. This connection is critical for developing targeted interventions.

Gap type: unexplained_observation Source paper: Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors. (2023, BMC Med, PMID:36600274)

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