How does controlled lysosomal membrane permeabilization induce autophagy without triggering cell death?

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Description

The study shows trehalose causes lysosomal membrane permeabilization (LMP) that paradoxically enhances autophagy rather than causing cytotoxicity. The molecular mechanisms preventing LMP-induced apoptosis while promoting beneficial autophagy remain unclear, which is critical for therapeutic safety.

Gap type: unexplained_observation Source paper: Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration. (2019, Autophagy, PMID:30335591)

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