How does APOE4 mechanistically increase TDP-43 pathology frequency in Alzheimer's disease?

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Description

The abstract identifies APOE4 association with increased TDP-43 pathology but the mechanistic link is unexplained. This connection could reveal novel therapeutic targets since APOE4 is the strongest genetic risk factor for AD.

Gap type: unexplained_observation Source paper: TDP-43 Pathology in Alzheimer’s Disease. (2021, Mol Neurodegener, PMID:34930382)

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