What are the neuron-specific effects of ALS-causing mutations on autophagy machinery?

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Description

While ALS-causing mutations impair autophagy factors, the neuron-specific effects remain incompletely defined according to the authors. This knowledge gap prevents precise understanding of selective neuronal vulnerability in ALS.

Gap type: open_question Source paper: Autophagy and ALS: mechanistic insights and therapeutic implications. (2022, Autophagy, PMID:34057020)

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