What mechanisms underlie neuronal resistance to autophagy induction compared to other cell types?

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Description

The abstract identifies that neurons show resistance to autophagy induction, but the mechanistic basis remains incompletely defined. Understanding this resistance is crucial for developing neuron-targeted autophagy therapies for ALS.

Gap type: unexplained_observation Source paper: Autophagy and ALS: mechanistic insights and therapeutic implications. (2022, Autophagy, PMID:34057020)

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