How do genetic variants at 6q16.2, 12q24.31, and 16p13.3 mechanistically regulate FBXL4 and RSRC1 expression?

psychiatric genetics open
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Description

The study identifies association between risk variants and gene expression changes, but the molecular mechanisms linking specific SNPs to altered FBXL4/RSRC1 expression remain unknown. Understanding these regulatory pathways is crucial for developing targeted therapeutic interventions.

Gap type: unexplained_observation Source paper: Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder. (2019, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, PMID:29728651)

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