What are the functional roles of FBXL4 and RSRC1 upregulation in MDD pathogenesis?

psychiatric neurobiology open
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Description

While FBXL4 and RSRC1 are upregulated in MDD brains, their specific contributions to disease mechanisms are unexplained. FBXL4 is involved in mitochondrial function and RSRC1 in RNA processing, but how their dysregulation leads to depressive phenotypes requires elucidation.

Gap type: unexplained_observation Source paper: Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder. (2019, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, PMID:29728651)

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