How does complement activation contribute to cognitive deficits across different neurodegenerative diseases?

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Description

The abstract mentions complement’s role in cognitive deficits but doesn’t explain the mechanistic pathways linking complement activation to specific cognitive impairments. This knowledge gap limits development of complement-targeted cognitive therapies.

Gap type: unexplained_observation Source paper: The Role of Complement in Synaptic Pruning and Neurodegeneration. (2021, ImmunoTargets and therapy, PMID:34595138)

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