What is the molecular mechanism linking microglial Piezo1 activation to C1q-C3 complement pathway initiation?

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Description

The study identifies Piezo1 as involved in bEV-induced synaptic pruning via the complement pathway but doesn’t explain how mechanosensitive Piezo1 channels connect to complement activation. This mechanistic gap limits understanding of how physical and immune signals integrate in neurodegeneration.

Gap type: unexplained_observation Source paper: Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-mediated synaptic pruning. (2025, Alzheimer’s & dementia : the journal of the Alzheimer’s Association, PMID:40731189)

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