What mechanisms underlie opioid receptor plasticity and how do they contribute to tolerance development?

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Description

The abstract mentions opioid receptor plasticity but doesn’t explain the mechanistic basis for how receptors change over time or how this plasticity drives tolerance. Understanding these mechanisms is critical for developing tolerance-resistant analgesics.

Gap type: unexplained_observation Source paper: Opioid Receptors. (2016, Annual review of medicine, PMID:26332001)

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