What are the specific molecular signals mediating IGF2BP1-dependent microglia-neuron crosstalk?

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Description

While co-culture experiments demonstrate that IGF2BP1-depleted microglia suppress neuronal ferroptosis through phenotypic reprogramming, the identity of the secreted factors or contact-dependent signals remains unknown. This knowledge gap limits understanding of the intercellular communication mechanisms.

Gap type: unexplained_observation Source paper: IGF2BP1 exacerbates neuroinflammation and cerebral ischemia/reperfusion injury by regulating neuronal ferroptosis and microglial polarization. (2025, Biochimica et biophysica acta. Molecular basis of disease, PMID:40294852)

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